Omics · study · 2026
Tuning BMP-Regulated Cell Differentiation in the Aortic Media by Mutating Matrix Gla Protein
Listed in NCBI GEO
The integrity of the vascular wall is crucial for maintaining the normal function of blood vessels.
Description
Matrix Gla protein (MGP), originally identified as an inhibitor of bone morphogenetic proteins (BMPs) and vascular calcification, is now recognized as a key vascular morphogen that guides cell differentiation across various tissues. In this study, we employed an MGP Pro64Gly knock-in mouse model alongside single-cell RNA sequencing to explore the role of MGP in mediating vascular cell differentiation.
The Pro64Gly mutation specifically impairs MGP's ability to bind to and inhibit BMPs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289219 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289219 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1221923 ncbi.nlm.nih.gov/bioproject/PRJNA1221923 ↗
project · from NCBI GEO
- PubMed 42460475 pubmed.ncbi.nlm.nih.gov/42460475 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE289219 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |