Omics · study · 2026
Multi‑omics analysis of anxiolytic gut–brain pathways induced by heat‑killed Lactobacillus brevis in zebrafish [Brain RNA-seq]
Listed in NCBI GEO
This study aimed to elucidate the molecular gut-brain pathways underlying the anxiolytic effects of heat-inactivated L. brevis SBC8803 using zebrafish as a translational model.
Description
Adult fish received oral SBC8803 and were assessed in the novel tank test. To interrogate mechanisms, we combined brain RNA sequencing with 16S rRNA gene profiling of the gut microbiota and performed integrative multi‑omics analyses to identify host gene expression changes and microbial functional alterations associated with anxiolysis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314984 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314984 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1394189 ncbi.nlm.nih.gov/bioproject/PRJNA1394189 ↗
project · from NCBI GEO
- PubMed 42254500 pubmed.ncbi.nlm.nih.gov/42254500 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314984 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |