Reconstruction and Analysis of a Genome-wide Metabolic Model of Sulfurospirillum multivorans

Supplementary information rec_progress.csv - Manual curation documentation cyc_access.py - lib for cyc2sbml cyc2sbml.py - python script to export data from pathwaytools to sbml sm.xml - sbml model of S. multivorans (bounds are set to a growth with 20mM pyruvate and 5% oxygen) smul-26_extended.xml - raw sbml model of S. multivorans (has to be complemented and run by test.py) test.py - python script to read, complement and simulate the sbml model of S. multivorans The recently sequenced and annotated genome of Sulfurospirillum multivorans provides insight into a versatile metabolism.

For instance, S. multivorans can mediate organohalide respiration which is a useful bioremediation process to degrade carcinogens like tetra chloroethene. Furthermore, a wide range of of electron donor oxidizing and electron acceptor reducing enzymes was identi?ed in S. multivorans and even oxygen can be used as terminal electron acceptor which is unusual for organohalide respiring organisms. Herein, I want to present a metabolic reconstruction of S. multivorans based on the genome annotation and experimental as well as expert knowledge.