Excel · study · 2026
Translocator Protein Deficiency Promotes Splenomegaly with Extramedullary Hematopoiesis after Sepsis
Listed in NCBI GEO
This study investigates the role of translocator protein (TSPO) in splenic immune responses following sepsis using a mouse cecal ligation and puncture (CLP) model.
Description
Bulk RNA sequencing of spleen tissue collected 17 days after sham or CLP surgery revealed that TSPO deficiency promotes splenomegaly characterized by red pulp expansion, enhanced erythropoiesis, and reduced immune responses. Gene expression and deconvolution analyses indicated decreased lymphocyte signatures and increased erythroblast and megakaryocyte signatures in TSPO knockout mice.
These findings suggest that TSPO plays a critical role in maintaining splenic immune homeostasis after sepsis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329160 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329160 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1458060 ncbi.nlm.nih.gov/bioproject/PRJNA1458060 ↗
project · from NCBI GEO
- PubMed 42160869 pubmed.ncbi.nlm.nih.gov/42160869 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329160 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |