Data · dataset · 2026
Supplementary data – Hungary’s Role in West Nile Virus Diversity and Spread in Europe – Nagy, 2026
Listed in ARP Research Data Repository
BACKGROUND West Nile virus (WNV) has become established across Europe, with Hungary serving as a key transmission hub since 2004.
Description
Following reduced activity during 2020–22, the 2024 season marked a resurgence with the largest geographical distribution ever recorded in Europe. AIM To analyse the 2024 WNV transmission season in Hungary using a One Health approach and characterise circulating strains within the European phylogeographic context using comprehensive genomic surveillance.
METHODS Complete and near-complete genome sequencing was performed on 55 specimens from 38 humans, 15 birds and two Culex pipiens mosquito pools using amplicon-based next-generation sequencing. Phylogeographic analysis incorporated 637 European WNV genome sequences (2004–24) with time-scaled Bayesian phylogenetic reconstruction and continuous spatial diffusion modelling. RESULTS Hungary reported 113 human WNV cases in 2024 (n = 111 autochthonous, 2 imported), a 3.7-fold increase from 2023 (incidence: 1.16 vs 0.31 per 100,000 population).
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Neuroinvasive disease predominated (92%, n = 104) with a 7.9% case fatality rate. All 55 sequenced strains belonged to WNV lineage 2. Phylogeographic analysis revealed Hungary's central role in European WNV dissemination since 2004, with multiple introductions and local diversification across distinct clades.
Continuous spatial modelling identified Hungary as a persistent transmission hub with bidirectional viral flow to neighbouring countries, contributing to northward expansion. CONCLUSION Hungary remains a critical WNV transmission hub in Central Europe with established endemicity of multiple lineage 2 clades. The analysis highlights Hungary's role as both a recipient and major source of European WNV diversity, emphasising the need for coordinated surveillance and climate-adapted preparedness strategies.
Links
Where it is published
- Dataverse dataset page repo.researchdata.hu/dataset.xhtml?persistentId=hdl%3A21.15109%2FARP%2FOLROUF ↗
landing page · from repo researchdata hu
- Persistent identifier hdl.handle.net/21.15109/ARP/OLROUF ↗
DOI / persistent id · from repo researchdata hu
Catalogue records · 1
- Dataverse API repo.researchdata.hu/api/datasets/:persistentId/?persistentId=hdl%3A21.15109%2FARP%… ↗
metadata API · from repo researchdata hu
Topics
- Stated by source
- Agricultural Sciences
- From keywords
- Life Sciences · Medicine & Health · One health
- Inferred from text
- Disease 75% · Genome sequencing 75% · Sequencing 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ARP Research Data Repository | hdl:21.15109/ARP/OLROUF | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:disease | enrichment · repo researchdata hu | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:420315 | mapping · repo researchdata hu | vocabulary-mapper@1.0.0 | keywords['One Health'] |
| concepts[field].dataverse_subject:agricultural-sciences | source · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | /subjects |
| concepts[modality].local:modality:genome-sequencing | enrichment · repo researchdata hu | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · repo researchdata hu | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | |
| description | source · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | /description |
| publication_date | source · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | |
| title | source · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | /name |
| updated_date | source · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 | |
| version_label | source · repo researchdata hu | connector:repo_researchdata_hu@1.0.0 |