Omics · study · 2026
RNA-seq of PRDX6 Knockdown and Control A223 Squamous Cell Carcinoma Cells Treated With HDAC Inhibitor Largazole
Listed in NCBI GEO
This dataset comprises RNA sequencing data generated from A223 squamous cell carcinoma cells with stable knockdown of PRDX6 or parental control, treated with either DMSO or 100 nM largazole (a class I histone deacetylase inhibitor) for 18 hours.
Description
The study investigates the role of PRDX6 in modulating ferroptosis susceptibility and inflammatory responses upon HDAC inhibition. Transcriptomic profiling was performed to evaluate pathway enrichment and gene expression signatures associated with ferroptosis, redox homeostasis, and immune activation.
Results demonstrate that PRDX6 knockdown enhances largazole-induced ferroptotic and inflammatory transcriptional programs, implicating PRDX6 as a redox rheostat suppressing immunogenic stress responses in squamous carcinoma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310671 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310671 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1366916 ncbi.nlm.nih.gov/bioproject/PRJNA1366916 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310671 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |