Excel · study · 2026
Treatment of mouse breast cancer cell line 4T1 with cepharanthine for RNA-seq
Listed in NCBI GEO
Breast cancer remains a significant global health challenge, with the highly aggressive 4T1 mouse mammary carcinoma cell line serving as a common model for studying triple-negative breast cancer (TNBC) due to its metastatic potential and resistance to therapy.
Description
Cepharanthine (CEP), a natural bisbenzylisoquinoline alkaloid, has demonstrated anti-inflammatory, immunomodulatory, and anti-cancer properties in various malignancies.
However, its molecular mechanisms in 4T1 cells remain poorly understood. In this study, we treated 4T1 cells with CEP and performed RNA sequencing (RNA-seq) to elucidate transcriptomic alterations induced by this compound.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297875 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297875 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1266664 ncbi.nlm.nih.gov/bioproject/PRJNA1266664 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE297875 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |