Data · study · 2026
Expression data from Pten, Apc, and Smad4 knockout prostate cancer mouse models
Listed in NCBI GEO
Prostate-specific deletions of tumor suppressor genes such as Pten, Apc, and Smad4 contribute to diverse molecular programs in prostate cancer.
Description
To investigate the transcriptional effects of these alterations, we generated genetically engineered mouse models with prostate-specific knockout of Pten alone or in combination with Apc or Smad4, using PB-Cre. We used microarrays to profile gene expression in tumors derived from different genotypes, comparing bulk tumor tissues and isolated cancer cells.
This dataset enables investigation of gene expression changes driven by distinct oncogenic drivers and tumor cell populations in prostate cancer.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302086 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302086 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1288497 ncbi.nlm.nih.gov/bioproject/PRJNA1288497 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE302086 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |