Omics · study · 2026
Paired Transcriptomic Profiling of Airspace and Peripheral Blood Mononuclear Cells in Severe ARDS
Listed in NCBI GEO
The main objective of our study was to determine whether central biologic processes inferred from transcriptomic profiling of distal airspace mononuclear cells are reflected among circulating peripheral blood mononuclear cells (PBMCs) during the acute phase of ARDS.
Description
To compare mononuclear cells from the airspaces and bloodstream we collected paired peripheral blood and non-bronchoscopic BAL (NBBAL) samples from mechanically ventilated patients with severe ARDS and enriched for mononuclear cells using density centrifugation and cryopreservation.
We then performed bulk RNA sequencing and evaluated gene expression profiles and gene expression networks between compartments.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326415 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326415 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445207 ncbi.nlm.nih.gov/bioproject/PRJNA1445207 ↗
project · from NCBI GEO
- PubMed 42313146 pubmed.ncbi.nlm.nih.gov/42313146 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326415 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |