Omics · study · 2026
Dural scRNA-seq in two organoids derived from malignant ascites of the same gastric cancer patient before (Primary) and after (Resistance) resistant to paclitaxel
Listed in NCBI GEO
We have employed a single sequencing(scRNA-seq) approach using 10× Genomics scRNAseq of organoids to study paclitaxel resistance in gastric cancer(GC).
Description
Patient-derived organoids (PDOs) can recapitulate majority aspects of tissue where they are derived from, in terms of specific molecular profiles, divergent phenotypes, concerning growth pattern, response to classical chemotherapy. This study represents the dural scRNA-seq in two organoids derived from malignant ascites of the same GC patient before (Primary) and after (Resistance) resistant to paclitaxel.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE321nnn/GSE321676 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE321676 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1429281 ncbi.nlm.nih.gov/bioproject/PRJNA1429281 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · Sequencing 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE321676 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |