Omics · study · 2026
Effect of Imeglimin on gene expression of renal cortex from diabetic mice
Listed in NCBI GEO
Imeglimin is an oral hypoglycemic agent marketed from Japan and has shown glucose-lowering effects in Japanese patients with type 2 diabetes in TIMES trials.
Description
However, it is not well known whether Imeglimin can affect diabetic kidney disease (DKD). To clarify this, we investigated the potential association between the effects of Imeglimin and DKD by using diabetic mice (DM) and cultured endothelial cell.
Administration of Imeglimin significantly lowered urinary albumin excretion in DKD, but did not significantly affect blood glucose and glycated albumin. RNA sequencing analysis of renal cortex indicated the upregulation of anti-oxidative, oxidative phosphorylation and AMPK signaling pathway and downregulation of inflammation, atherosclerosis and reactive oxygen species. Additionally, Imeglimin decreased the mRNA expressions of TNF-α, F4/80 and Fibronectin on renal cortex of DKD.
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In parallel with the findings that Imeglimin reduced the protein expression of Fibronectin on renal cortex of DKD, renal histological fibrosis was significantly increased in DM compared with NDM, which was significantly reduced by Imeglimin. In vitro study, HG induced the mRNA expressions of Nlrp3, Vcam-1 and NOX4, which were downregulated by Imeglimin. These results suggest that Imeglimin could improve albuminuria associated with partial suppression of inflammatory and fibrotic markers in DKD.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344280 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344280 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1515187 ncbi.nlm.nih.gov/bioproject/PRJNA1515187 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE344280 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |