Omics · study · 2026
Transcriptomic profiling of ALIX knockout mesenchymal stem cells from subcutaneous white adipose tissues in mice under high-fat diet feeding
Listed in NCBI GEO
Cells throughout the body release small extracellular vesicles (sEVs), including exosomes, which function as modulators of metabolism.
Description
In this study, we performed RNA sequencing of mesenchymal stem cells (MSCs) derived from subcutaneous white adipose tissue isolated from control and Pα-ALIXKO mice, in which ALIX, a key regulator of sEV biogenesis, was selectively deleted in PDGFRα⁺ tissue-resident mesenchymal progenitors.
Mice were subjected to high-fat diet feeding. This dataset enables the analysis of transcriptomic changes in MSCs derived from control and Pα-ALIXKO mice.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326593 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326593 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445978 ncbi.nlm.nih.gov/bioproject/PRJNA1445978 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326593 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |