Omics · study · 2026
Transcriptomic profiling of AML cell lines MV4-11 and Kasumi-1 treated with CK1α degrader PinA1
Listed in NCBI GEO
Acute myeloid leukemia (AML) is characterized by dysregulated transcriptional programs that support malignant proliferation and survival.
Description
Casein kinase 1 alpha (CK1α) has been implicated in the regulation of p53 signaling and represents a potential therapeutic target. In this study, we aimed to investigate whether CK1α degradation induces broad transcriptomic changes in a p53-dependent manner.
To address this, we performed RNA sequencing (RNA-seq) in two human AML cell lines with distinct TP53 status: MV4-11 (TP53 wild-type) and Kasumi-1 (TP53 mutant). Cells were treated with a CK1α degrader (PinA1) or vehicle control, followed by transcriptomic profiling. Comparative analysis was conducted to assess the extent and nature of gene expression changes induced by CK1α degradation.
Read the rest (1 more)
Notably, this study was designed to evaluate whether CK1α targeting leads to more pronounced transcriptional alterations in TP53 wild-type cells compared to TP53-mutant contexts. Our data provide insights into the p53-dependent transcriptional consequences of CK1α degradation and support its potential as a therapeutic strategy in AML.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326946 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326946 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1446174 ncbi.nlm.nih.gov/bioproject/PRJNA1446174 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326946 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |