Omics · study · 2026
Transcriptomic Analysis to Elucidate Key Genes and Signaling Pathways Involved in the Promotion of Periodontitis by Hypertension
Listed in NCBI GEO
To identify key genes and metabolites that promote the progression of periodontitis in the context of hypertension through transcriptomic analyses.
Description
Rat models of periodontitis and periodontitis combined with hypertension were established, with healthy rats serving as the control group. Periodontal tissues from each group were collected for transcriptomic sequencing.
Subsequently, differential mRNA, lncRNA and circRNA were analyzed in the periodontitis with hypertension group compared to the control group, as well as in the periodontitis with hypertension group compared to the periodontitis group. Gene Ontology and KEGG enrichment analyses were performed, and a joint analysis of differential genes and metabolites was conducted. The differential genes and metabolites were primarily enriched in the pathways of arginine biosynthesis, cysteine and methionine metabolism, and biosynthesis of amino acids.
Read the rest (1 more)
Hypertension may promote the development of periodontitis by altering interferon-inducible genes-related pathway.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295190 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295190 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1253679 ncbi.nlm.nih.gov/bioproject/PRJNA1253679 ↗
project · from NCBI GEO
- PubMed 41975020 pubmed.ncbi.nlm.nih.gov/41975020 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE295190 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |