RNA sequencing data: The effect of early and late erythropoietin in an anemic OIR rat model

Neither early nor late Epo administration altered percent avascular or neovascular area in anemic or non-anemic pups. In anemic rat retinas, Epo had negligible molecular impact. In contrast, in non-anemic retinas, late Epo reduced retinal hemorrhages and pro-inflammatory cytokines along with altering the retinal transcriptome to implicate activation of apoptosis and inhibition of vascular development.

Therefore, we conclude that neither early nor late Epo alter anatomical OIR severity or exert clinically relevant molecular effects during anemia, but late Epo modulates transcriptomic and inflammatory pathways in non-anemic retinas.