Omics · study · 2026
Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy Associated Microglia
Listed in NCBI GEO
In acquired epilepsy, an inciting injury is believed to trigger epileptogenesis, leading to dysfunctional networks that have both a propensity to give rise to seizures as well as impair normal cogntition.
Description
We have performed single nucleus sequencing on hippocampal tissue from a mouse model of temporal lobe epilepsy. The tissue was collected during time-points at which seizures and memory deficts are just begining to emerge.
We anticipate this dataset will allow for the identification of key changes underlying epileptogenesis and provide candidates for therapeautic intervention.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306031 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306031 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1308983 ncbi.nlm.nih.gov/bioproject/PRJNA1308983 ↗
project · from NCBI GEO
- PubMed 41867871 pubmed.ncbi.nlm.nih.gov/41867871 ↗
publication · from NCBI GEO
- PubMed 42662868 pubmed.ncbi.nlm.nih.gov/42662868 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306031 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |