Omics · study · 2026
The subcoeruleus nucleus mediates specific immune response in the lungs via sympathetic nerve
Listed in NCBI GEO
In this study, single-cell RNA sequencing (scRNA-seq) was conducted on lung tissues from adult C57BL/6J male mice under various experimental conditions.
Description
The mice were divided into control, LPS-treated, and SLC-Gq activation + LPS groups. Lung tissues were collected three days after intratracheal administration of PBS or LPS.
Single-cell suspensions were prepared and processed using the BD Rhapsody system for scRNA-seq. Our objective was to investigate cell type-specific responses and transcriptional profiles in the lung microenvironment following LPS challenge, with or without SLC activation. The results provide a comprehensive single-cell atlas of mouse lung immune responses and potential targets for future interventions.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303253 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303253 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1290695 ncbi.nlm.nih.gov/bioproject/PRJNA1290695 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303253 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |