Omics · study · 2026
Therapeutic HPV16 E7 Vaccination with CD137 Agonism Induces Tumour Regression and Durable Immunity in Mice
Listed in NCBI GEO
Therapeutic HPV16 E7 vaccination was evaluated in the syngeneic TC-1 tumour model in female C57BL/6 mice.
Description
Bulk RNA sequencing was performed on pooled, non-adherent mononuclear cell-enriched fractions prepared from subcutaneous tumour samples. The dataset compares PBS or vehicle controls, MPLA-adjuvanted wild-type E7 vaccination, MPLA-adjuvanted recombinant overlapping peptide E7 (ROP-E7) vaccination, anti-CD137 (4-1BB) agonism, and ROP-E7 plus anti-CD137 combination therapy.
The study was designed to characterise treatment-associated changes in tumour immune and stromal transcriptional signatures.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347031 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347031 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1527528 ncbi.nlm.nih.gov/bioproject/PRJNA1527528 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE347031 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |