Omics · study · 2026
GZMK-expressing tissue-resident memory CD8+ T cells mediate human intestinal acute graft-versus-host disease [INT]
Listed in NCBI GEO
Tissue-resident memory T cells (TRM) have recently emerged as crucial cellular players for murine acute graft-versus-host disease (aGVHD) development.
Description
However, the role of distinct subsets of CD8+TRM cells in human intestinal aGVHD is not well known yet. Herein,we combined multiplex immunohistochemical staining with single-cell RNA sequencing to elucidate the differentiation trajectory, lineage commitment, clonal expansion and functional properties of distinct CD8+TRM cell subsets in human intestinal aGVHD.
We revealed seven functionally distinct CD8+TRM subsets and innovatively uncovered a significant GZMK+CD8+TRM subset. GZMK+CD8+TRM subset mediated human intestinal aGVHD by exhibiting enhanced clonal expansion, IFN signaling pathway-associated proinflammatory, and lineage bifurcation differentiation properties. High GZMK+CD8+TRM subset infiltration is correlated with human intestinal aGVHD severity and poor prognosis.
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Therefore, we demonstrated that human intestinal aGVHD is in good part mediated by pivotal GZMK+CD8+TRM subset. Targeting key CD8+TRM cell subsets could be a new treatment approach in the human intestinal aGVHD.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318630 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318630 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1419493 ncbi.nlm.nih.gov/bioproject/PRJNA1419493 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318630 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |