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Excel · study · 2026

Transcriptome analysis of TNFα or necroptosis-induced stimulation in the NCI-H441 cell line with RIPK3 knocked down by siRNA.

Listed in NCBI GEO

We aimed to elucidate the role of RIPK3 in lung adenocarcinoma by analyzing expression variations through RNA sequencing.

Description

To achieve this, we suppressed the expression of RIPK3 in the NCI-H441 lung adenocarcinoma cell line, which highly expresses this gene, using multiple siRNAs. We then subjected the cells with RIPK3 knockdown to TNFα stimulation and necroptosis-inducing stimuli.

As a result, we observed changes in the expression of genes involved in chemokine expression and the production of interferons (IFNs)

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Stated by source
Expression profiling by high throughput sequencing · Homo sapiens
From keywords
Life Sciences
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RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE27021115 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title