A new proline-containing flavonol glycoside from Caragana leucophloea Pojark

One new proline-containing flavonol glycoside, namely kaempferol-3- O -methyl-7- O -β-d-glucopyranosyl-8-(1-methyleneproline)-4′- O -β-d-glucopyranoside ( 1 ), together with 15 known flavonoids, 3- O -methylkaempferol ( 2 ), 3- O -methylquercetin ( 3 ), quercetin ( 4 ), kaempferol ( 5 ), apigenin ( 6 ), rhamnazin ( 7 ), astragalin ( 8 ), alquds ( 9 ), quercitrin ( 10 ), rutin ( 11 ), isoquercitrin ( 12 ), apigetrin ( 13 ), myricitrin ( 14 ), hesperidin ( 15 ) and calycosin-7- O -β-d-glucopyranoside ( 16 ) were isolated from the aerial parts of Caragana leucophloea Pojark.

(Leguminosae). Their structures were determined on the basis of spectroscopic analyses and by comparison with literature data. Compounds 2 – 4 revealed a strong antimicrobial activity with minimum inhibitory concentration values of 12.5–150 μg/mL and median inhibitory concentration (IC 50 ) values of 7.42–76.61 μg/mL.