Excel · study · 2026
Obesity and Diabetes Increase SARS-CoV-2 Susceptibility with Tissue-Specific Immune, Metabolic, and Gut Microbial Dysregulation
Listed in NCBI GEO
Obesity and diabetes are major risk factors for SARS-CoV-2-associated cardiac injury, but the molecular mechanisms underlying increased susceptibility remain incompletely understood.
Description
This study generated bulk RNA sequencing data from cardiac tissue collected from 24-week-old male obese diabetic (db/db) and wildtype mice seven days after infection with murine-adapted SARS-CoV-2. Obese diabetic mice exhibited compromised innate and adaptive immune responses, including dysregulated Wnt signaling and impaired IFN-γ activation.
These data provide a resource for investigating cardiac-specific transcriptional responses to SARS-CoV-2 infection in the setting of obesity and diabetes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342458 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342458 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1507907 ncbi.nlm.nih.gov/bioproject/PRJNA1507907 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Heart 65% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342458 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |