Omics · study · 2026
Beta-hydroxybutyrate enhances mitochondrial energy metabolism through histone beta-hydroxybutyrylation
Listed in NCBI GEO
Beta-hydroxybutyrate (BHB) regulates gene expression through modulation of post-translational histone modifications, including histone beta-hydroxybutyrylation.
Description
In human renal tubular epithelial cells challenged with hydrogen peroxide, pretreatment with sodium beta-hydroxybutyrate (BHBNa) significantly upregulated global histone beta-hydroxybutyrylation marks, specifically enhancing beta-hydroxybutyrylation at histone H3 lysine 4 (H3K4bhb) compared to hydrogen peroxide treatment alone.
To investigate whether BHB enhances mitochondrial energy metabolism via this epigenetic mechanism, we performed chromatin immunoprecipitation sequencing (ChIP-seq) specifically targeting H3K4bhb.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329902 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329902 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1290643 ncbi.nlm.nih.gov/bioproject/PRJNA1290643 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329902 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |