Omics · study · 2026
Transcriptomic and H3K27ac chromatin responses of human microglia to acute PFOS exposure and recovery
Listed in NCBI GEO
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants associated with adverse neurological effects, but their impact on microglial gene regulation remains unclear.
Description
In this study, human HMC3 microglial cells were exposed to vehicle control or perfluorooctane sulfonate (PFOS) at 25 or 50 µM for 24 hours. RNA sequencing was used to characterize transcriptomic changes, and H3K27ac CUT&Tag was used to profile active chromatin.
Additional samples were collected after PFOS withdrawal and a 24-hour recovery period to assess persistent molecular alterations. These datasets support integrated analysis of acute and persistent PFOS-induced transcriptomic and epigenetic changes in human microglia.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342612 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342612 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1508658 ncbi.nlm.nih.gov/bioproject/PRJNA1508658 ↗
project · from NCBI GEO
- PubMed 40419075 pubmed.ncbi.nlm.nih.gov/40419075 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342612 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |