Omics · study · 2026
DC-SIGN+ Macrophages alleviates Non-Alcoholic Steatohepatitis by modulating inflammatory cytokine secretion
Listed in NCBI GEO
The modulation of immune responses by innate immune receptors plays a pivotal role in the progression of non-alcoholic steatohepatitis (NASH).
Description
In this study, we aim to comprehensively dissect the involvement of the C-type lectin receptor DC-specific-ICAM3-grabbing-nonintegrin (DC-SIGN) in NASH progression. RNA sequencing was conducted on liver samples obtained from mice fed either a control diet or a HFHC diet inducing NASH for 16 weeks.
At 8 weeks post feeding, animals were transduced via tail vein with Adeno-Associated Virus 9 (AAV9) expressing CD68 promoter-driven human DC-SIGN (hDC-SIGN) or GFP control. Data obtained from the transcriptomic profiles indicated that macrophage-specific delivery of hDC-SIGN strongly attenuated liver metabolic and inflammatory abnormalities, leading to the amelioration of NASH progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE264nnn/GSE264747 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE264747 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1104132 ncbi.nlm.nih.gov/bioproject/PRJNA1104132 ↗
project · from NCBI GEO
- PubMed 41270396 pubmed.ncbi.nlm.nih.gov/41270396 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE264747 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |