Omics · study · 2026
mRNA expression profile of OVA-specific Th2 cells from cLNs of mice injected with or without OVA-specific IgE after nasal OVA challenge
Listed in NCBI GEO
To elucidate the role of systemic antigen-specific IgE in the local activation of Th2 cells during allergic rhinitis (AR), we employed an adoptive transfer-based AR mouse model.
Description
Mice were adoptively sensitized with OVA-specific IgE (OVA-IgE) and/or in vitro-differentiated OVA-specific Th2 (OVA-Th2) cells, followed by intranasal OVA challenge. Single-cell RNA sequencing was performed to analyze the mRNA expression profiles of Th2 cells isolated from cervical lymph nodes of mice injected with or without OVA-specific IgE.
Freshly cultured OVA-Th2 cells were included as controls.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309936 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309936 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1364016 ncbi.nlm.nih.gov/bioproject/PRJNA1364016 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309936 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |