Clinical Laboratory Characteristics and Driver Gene Mutation Features in Ph-negative Myeloproliferative Neoplasm Patients with Dual Driver Gene Positivity

Compared to the single driver gene positive group, the dual driver gene positive group had a significantly higher risk of bleeding [4.1% (8/194) vs. 33.3% (3/9), P=0.008] and a higher proportion of non-classical mutations [3.6% (7/194) vs. 44.4% (4/9), P=0.001]. There was no statistical difference between the two groups in terms of age, thrombosis incidence, splenomegaly, and routine blood test indicators. During the follow-up period, 1 case in the dual driver gene positive group died due to cerebrovascular disease, with no leukemia transformation or disease-related deaths in the remaining cases.Conclusion: The patients of Ph-negative MPN with dual driver gene positivity mayhave a higher risk of bleeding and a more complex gene mutation profile.