Omics · study · 2026
Transcriptomic profiling of Candida glabrata under eltrombopag (ETP) treatment
Listed in NCBI GEO
This study aimed to investigate the transcriptional responses of Candida glabrata to eltrombopag (ETP) treatment.
Description
RNA sequencing analysis identified 122 differentially expressed genes under ETP treatment, including 44 upregulated and 78 downregulated genes. The upregulated genes were associated with stress responses and iron homeostasis, whereas the downregulated genes were mainly related to mitochondrial respiration.
GO and KEGG enrichment analyses showed that ETP treatment was associated with changes in pathways related to mitochondrial function, iron-dependent processes, and cellular stress responses. These data provide transcriptomic evidence that ETP affects iron homeostasis and mitochondrial respiration-related pathways in C. glabrata.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333498 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333498 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1471188 ncbi.nlm.nih.gov/bioproject/PRJNA1471188 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE333498 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |