Excel · study · 2026
Transcriptomic profiling of HTR-8/SVneo cells under normal and MLEC knockdown conditions
Listed in NCBI GEO
This dataset comprises the gene expression profiles of HTR-8/SVneo cells under WT and MLEC knockdown conditions.
Description
RNA sequencing (RNA-seq) was conducted to examine the effects of MLEC depletion on gene expression, with the goal of elucidating its role in trophoblast function, including unfolded protein response (UPR), endoplasmic reticulum stress (ER Stress) and ER Stress-induced apoptosis. This dataset offers valuable insights into the molecular mechanisms governed by MLEC in trophoblast biology and its potential relevance to pregnancy-related disorders.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294525 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294525 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1250444 ncbi.nlm.nih.gov/bioproject/PRJNA1250444 ↗
project · from NCBI GEO
- PubMed 42183838 pubmed.ncbi.nlm.nih.gov/42183838 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294525 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |