Omics · study · 2026
Targeting Thioredoxin Reductase 1 (TrxR1) Uncovers Ferroptosis-Linked Transcriptional Vulnerabilities in Lung Cancer
Listed in NCBI GEO
Bulk RNA sequencing revealed that KRAS-WT and EGFR-MUT LC cells, which are sensitive to TrxR1 inhibitors (CS47 and auranofin), undergo extensive transcriptional reprogramming, unlike the treatment-resistant KRAS-mutant (KRAS-MUT) cells.
Description
TrxR inhibition triggers robust transcriptional activation of glutathione biosynthesis, antioxidant defenses, and iron metabolism in KRAS-WT lung cancer cells. This adaptive response, while aimed at maintaining redox balance, is ultimately overwhelmed, leading to ferroptotic cell death.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300378 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300378 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1280173 ncbi.nlm.nih.gov/bioproject/PRJNA1280173 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE300378 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |