Data · collection · 2015
Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108
Listed in DataCite
Xylaria cf. cubensis PK108 was identified by its distinctive morphological characteristics and its internal transcribed spacers sequence analysis.
Description
The chromatographic separation and structural elucidation based on spectroscopic analysis of fungal crude extracts led to 10 compounds; tryptoquivaline L ( 1 ), fiscalin C ( 2 ), epi -fiscalin C ( 3 ), cytochalasin D ( 4 ), ergosterol ( 5 ), ergosterol peroxide ( 6 ), chevalone C ( 7 ), xylaranol B ( 8 ), helvolic acid ( 9 ) and cyclo-(l-Pro-l-Leu) ( 10 ).
The bioassay screening showed that 4 displayed cytotoxicity against KB and NCI-H187 cancer cell lines with IC 50 values of 3.25 and 5.95 μg mL − 1 . 6 exhibited cytotoxicity against NCI-H187 with an IC 50 value of 5.81 μg mL − 1 . 7 and 9 showed antimalarial activity with IC 50 values of 25.00 and 6.25 μg mL − 1 , respectively. This result establishes Xylaria as broad spectrum bioactive compound producers.
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Where it is published
- Repository landing page figshare.com/collections/Antimalarial_and_cytotoxic_constituents_of_i_Xylar… ↗
landing page · from DataCite
- Repository landing page figshare.com/collections/Antimalarial_and_cytotoxic_constituents_of_i_Xylar… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2042159 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.c.2042159.v1 ↗
DOI / persistent id · from DataCite
Documentation and papers
- CC-BY creativecommons.org/licenses/by/3.0/us ↗
license · from DataCite
- IsSupplementTo 10.1080/14786419.2015.1017724 doi.org/10.1080/14786419.2015.1017724 ↗
publication · from DataCite
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2042159.v1 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.2042159 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2042159.v1 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.c.2042159 ↗
catalogue entry · from DataCite
Topics
Provenance · 2 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.2042159 | 15 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.c.2042159.v1 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
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| concepts[disease].local:disease:cancer | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:chemical-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:chemical-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:earth-and-related-environmental-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:earth-and-related-environmental-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:physical-sciences | source · DataCite | connector:datacite@1.0.0 | |
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| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |