Excel · study · 2026
Cordyceps sinensis extract mixture, and two active components D-Mannitol and Ergosterol associated with neuroprotective effects in H2O2-induced PC12 and SH-SY5Y cell models
Listed in NCBI GEO
Disorders of redox homeostasis and the excessive release of hydrogen peroxide (H2O2) are pivotal events in the pathogenesis of epilepsy, contributing to neuronal hyperexcitability, mitochondrial dysfunction, and subsequent cell death.
Description
Cordyceps sinensis (C. sinensis), a traditional Chinese medicine renowned for its tonic properties, has been traditionally used to alleviate a variety of ailments. Emerging evidence suggests that C. sinensis and its active constituents possess significant sedative and anti-inflammatory effects.
Transcriptomic sequencing was conducted on the H2O2-induced cell lines treated with varying concentrations of the C. sinensis mixture and monomers to validate and integrate the findings. This research investigates the neuroprotective and anticonvulsant effects of C. sinensis extract against H2O2-induced oxidative stress and excitotoxicity in neuronal models of epilepsy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331260 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331260 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1467573 ncbi.nlm.nih.gov/bioproject/PRJNA1467573 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE331260 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |