Omics · study · 2026
Transcription Elongation Factor SPT6 Maintains Epidermal Homeostasis and Suppresses Skin Inflammation in Mice
Listed in NCBI GEO
We employed single-cell RNA sequencing (scRNA-seq) using 10x Genomics technology to investigate the impact of Supt6 epidermis-specific knockout on epidermal homeostasis in mice.
Description
The histone chaperone SPT6 is a central regulator of genomic stability. Our previous studies have shown that SPT6 promotes epidermal differentiation by regulating transcriptional elongation in human epidermal stem/progenitor cells, but its in vivo role remains unclear.
Our research has discovered for the first time that the transcriptional elongation factor SPT6 regulates skin inflammation, hair follicle development, and wound healing, providing a novel therapeutic target for clinical treatment of psoriasis and related skin disorders.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294435 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294435 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1249452 ncbi.nlm.nih.gov/bioproject/PRJNA1249452 ↗
project · from NCBI GEO
- PubMed 41922599 pubmed.ncbi.nlm.nih.gov/41922599 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294435 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |