Evolution of TGFbeta and other relevant molecules

Presented here are a selection of figures relating to the evolution of bona fide TGFbeta, as well as it's binding partners and activators. This data was originally supplementary material for a paper in cytokine and growth factor reviews entitled "Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation." Robertson I B, Rifkin D B. (dx.doi.org/10.1016/j.cytogfr.2013.06.003), but for editorial reasons it was not included in the final article.

For figure description please see individual figshare entries: Data file for TGFbeta superfamily tree: dx.doi.org/10.6084/m9.figshare.745316 CEM mutations: dx.doi.org/10.6084/m9.figshare.745297 GARP evolution: dx.doi.org/10.6084/m9.figshare.745299 Integrin activation table: dx.doi.org/10.6084/m9.figshare.745300 TSP1 evolution dx.doi.org/10.6084/m9.figshare.745314 ROS sensitivity: dx.doi.org/10.6084/m9.figshare.745315