Omics · study · 2026
A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesis
Listed in NCBI GEO
Zika virus (ZIKV) nonstructural protein 5 (NS5) antagonizes host antiviral immunity, but how this immune-evasion activity is regulated to support viral fitness and pathogenesis remains incompletely understood.
Description
In this study, we investigated the functional importance of NS5 residue L162 by comparing wild-type ZIKV with the ZIKV-NS5L162A and ZIKV-NS5L162G mutants. RNA sequencing was performed in A549 cells that were mock infected or infected with wild-type or mutant ZIKV to characterize virus-induced transcriptional responses and determine how substitutions at NS5 residue L162 alter host gene expression.
These data provide a genome-wide resource for defining NS5-dependent regulation of innate immune and antiviral responses.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344436 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344436 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1515861 ncbi.nlm.nih.gov/bioproject/PRJNA1515861 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE344436 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |