19,040 datasets

data.gov.gr2026 · Excel spreadsheet · unknown

Ο ετήσιος ΠΥ του Δήμου Ορχομενού για το έτος 2026

Data.gov.ie2026 · Excel spreadsheet · unknown

NCBI GEO2026 · RNA sequencing · 9 samples

This work explores tissue-specific biomimetic functional materials and investigates the regulatory mechanisms of materials on cells, offering a highly promising solution for the manufacturing of centimeter-sized injectable liver tissue.

NCBI GEO2026 · RNA sequencing · 18 samples

DNA methylation regulates transcription, yet the demethylation of canonical elements like promoter CpG islands exhibits inconsistent correlations with gene activation. We hypothesized that causal regulatory elements are defined by biophysical hypersensitivity. Profiling 24 whole-genome bisulfite sequencing samples across diverse human and murine models, we identified Methylation Mesa, narrow (~45-

NCBI GEO2026 · RNA sequencing · 6 samples

Spermatogonial stem cells (SSCs) are required for initiating and maintaining normal spermatogenesis, and notably, they have significant applications in both reproductive and regenerative medicine owing to their great plasticity with de-differentiation and trans-differentiation potentials. Nevertheless, molecular mechanisms regulating human SSC fate determinations and male fertility remain elusive.

NCBI GEO2026 · RNA sequencing · 204 samples

RNA sequencing was performed on human stem cell-derived neuronal cultures across developmental and experimental conditions, including differentiated neurons exposed for 24 h to the mitochondrial complex I inhibitor rotenone at 0.06, 0.25, 0.5 or 1 µM. The transcriptomic data were generated to support characterisation of human dopaminergic neuronal metabolism and integration with quantitative exome

NCBI GEO2026 · RNA sequencing

We compared gene expression of aged and young oligodendrocyte progenitor cells (OPC) and identified differentially expressed genes.

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 18 samples

Precise and rapid control over cellular protein levels is essential to dissect complex biological systems. Chemical genetic approaches such as dTAG, in which a target is fused to a degron tag (FKBP12F36V) and degraded upon small molecule-mediated recruitment of E3 ligases, have enabled rapid and tunable control over protein abundance. However, no analogous tool exists to precisely increase protein

NCBI GEO2026 · RNA sequencing · 12 samples

In young animals, oligodendrocyte progenitor cells (OPCs) undergo robust differentiation, progressing through stages to become pre-myelinating oligodendrocytes (Pre-OL) and ultimately myelinating oligodendrocytes (OLs). However, OPCs in aged animals are limited in their differentiation ability. This disrupts myelin maintenance in the central nervous system (CNS), leading to a lack of remyelination

NCBI GEO2026 · Methylation profiling by genome tiling array · 40 samples

This project aims to identify CNVs of intracranial and extracranial germ cell tumors in the Thai population. Formalin-fixed paraffin-embedded tissues (FFPET) from intracranial (IGCTs) and extracranial germ cell tumors (EGCTs) were extracted and analyzed using SNP microarray, and somatic CNVs were also investigated. Pathway enrichment analysis and associations between significant CNVs, clinical par

NCBI GEO2026 · RNA sequencing · 46 samples

Shortly after mitosis, a wave of hyper-transcription reactivates the genome, especially in mouse embryonic stem (ES) cells, where rapid reactivation is essential for self-renewal and pluripotency. While recent work has illuminated how specific groups of genes are reactivated, whether dedicated mechanisms enable the global, efficient and accurate post-mitotic reactivation of the genome remains unkn

NCBI GEO2026 · RNA sequencing · 9 samples

Proline/arginine-rich end leucine-rich repeat protein (PRELP) is an extracellular matrix-associated protein involved in tissue remodeling and immune regulation. This study investigates PRELP-associated transcriptional changes in human melanoma using bulk RNA sequencing of PRELP-low, PRELP-high, and PRELP + Toll-like receptor 2 (TLR2) co-transfected BUF1088 cells. PRELP-high cells were generated by

NCBI GEO2026 · RNA sequencing · 12 samples

Interleukin-6 (IL-6) is a pleiotropic cytokine that drives macrophage functions ranging from tissue homeostasis to inflammation, yet how STAT3 specifies these divergent outcomes remains unclear. By integrating transcriptomic and epigenomic profiling with selective STAT3 degradation, we show that STAT3 controls IL-6-induced epigenomic remodeling and restrains a latent STAT1-associated interferon pr

NCBI GEO2026 · RNA sequencing · 4 samples

A novel method for the efficient construction and rapid vascularization of functional hepatocyte aggregates in vitro has been developed in this research.

NCBI GEO2026 · RNA sequencing · 38 samples

Cardiovascular disease (CVD) etiology is strongly influenced by lead (Pb) exposure, but the underlying molecular and functional mechanisms are unclear, particularly during development. Using human induced pluripotent stem cell (iPSC) derived cardiomyocytes, we examined the effects of human-relevant Pb exposure during ventricular cardiomyocyte differentiation on transcription at several time points

NCBI GEO2026 · RNA sequencing · 6 samples

Pathological cardiac remodeling under chronic stress load is a key process in the progression of heart failure (HF), but its underlying molecular mechanisms are not yet fully understood, which limits the development of therapeutic approaches. In this study, we identified serine/threonine kinase 39 (STK39) as a key mediator, showing that it is significantly upregulated in human hypertrophic hearts

NCBI GEO2026 · Text · 2 samples

Ribonuclease Z enzymes remove 3′ trailers from precursor tRNAs. In human cells, ELAC2/RNase ZL matures nuclear and mitochondrial pre-tRNAs and releases the tRNA-like small RNAs mascRNA and menRNA from the 3′ ends of MALAT1 and NEAT1. Instead, the cytosolic short paralog ELAC1/RNase ZS repairs ANKZF1-cleaved tRNAs, with its wider substrate repertoire remaining unresolved. Here, we investigate the r

NCBI GEO2026 · RNA sequencing · 14 samples

Circadian rhythms coordinate daily fluctuations in physiology and behavior, yet their organization within primary sensory pathways remains poorly defined. Although somatosensory responsiveness varies across the day-night cycle, it is unclear whether peripheral sensory circuits possess molecular mechanisms for temporal regulation. Here, we demonstrate that the spinal-peripheral sensory axis harbors

NCBI GEO2026 · RNA sequencing · 10 samples

The developing mammalian embryo is guided by the continuously changing signals that it receives from maternal tissues and its microenvironment. The dynamic cell-cell and cell-environment interactions that together shape the embryo largely remained unexplorable until the advance of stem cell-based embryo models. These revealed the self-organizing properties of cells in response to endogenous and ex

NCBI GEO2026 · RNA sequencing · 20 samples

Background: Asthma is a chronic respiratory disease characterized by airway inflammation, airway hyperresponsiveness (AHR) and airway remodeling. Mast cell numbers are increased in asthmatic airways and contribute to bronchoconstriction and inflammation; yet their role in asthma development remains elusive. Objective: To investigate mast cell contributions to allergic asthma by pharmacologically t

NCBI GEO2026 · RNA sequencing · 37 samples

Early-life exposure to high-fat diet (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies reported the impact of maternal HF on this structure. We assessed the effects of maternal HF during lactation on physiological, metabolic and cognitive parameters in young adult offspring mice. T

NCBI GEO2026 · RNA sequencing · 12 samples

Interleukin-6 (IL-6) is a pleiotropic cytokine that drives macrophage functions ranging from tissue homeostasis to inflammation, yet how STAT3 specifies these divergent outcomes remains unclear. By integrating transcriptomic and epigenomic profiling with selective STAT3 degradation, we show that STAT3 controls IL-6-induced epigenomic remodeling and restrains a latent STAT1-associated interferon pr

NCBI GEO2026 · RNA sequencing · 14 samples

To identify the pathogens and pathogen targeting genes/RNAs, presence of ribosomal RNA, splice variants, and lncRNA are considered.

NCBI GEO2026 · RNA sequencing · 8 samples

Adipose tissue expansion in obesity frequently outpaces vascularization, triggering hypoxia, fibrosis, and metabolic dysfunction. The molecular mechanisms coordinating adaptive angiogenesis during this expansion remain poorly understood. Here, we demonstrate that macrophage-specific deletion of Transcription Factor EB (Tfeb) in high-fat diet-fed mice exacerbates epididymal white adipose tissue (eW

NCBI GEO2026 · RNA sequencing · 8 samples

Interleukin-6 (IL-6) is a pleiotropic cytokine that drives macrophage functions ranging from tissue homeostasis to inflammation, yet how STAT3 specifies these divergent outcomes remains unclear. By integrating transcriptomic and epigenomic profiling with selective STAT3 degradation, we show that STAT3 controls IL-6-induced epigenomic remodeling and restrains a latent STAT1-associated interferon pr