Data · study · 2026
NanoString nCounter study of ICCR-engineered human T cells compared to nontransduced T cells.
Listed in NCBI GEO
This study aimed to investigate the targeting efficacy of ICAM1-specific chimeric costimulatory receptor (ICCR)-T cells on solid tumor and to study the molecular changes that underlie ICCR functional activity.
Description
This objective was addressed by demonstrating superior ICCR-T cell targeting efficacy using allogeneic and autologous ICCR-T cells on anaplastic thyroid cancer (ATC) cells in vitro. ICCR-T cell activity was also tested in vivo using ATC xenografts.
We delineated the mechanism by which ICCR enhances T cell proliferation and selective activation by analyzing downstream signal pathway activation, gene expression, and TCR sequencing.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289228 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289228 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1221938 ncbi.nlm.nih.gov/bioproject/PRJNA1221938 ↗
project · from NCBI GEO
- PubMed 42043451 pubmed.ncbi.nlm.nih.gov/42043451 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE289228 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |