Data · study · 2026
Placenta gene expression postdevelopmental exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice
Listed in NCBI GEO
Multiple per- and polyfluoroalkyl substances (PFAS) have been associated with adverse pregnancy and birth outcomes in humans and animals.
Description
While the underlying mechanism(s) through which exposure to PFAS may induce these adverse pregnancy and birth outcomes is not known, it has been posited that the placenta may be an important target and/or mediator. We performed whole-transcriptome gene expression analysis to investigate the molecular mechanisms underpinning the effects on placental health after prenatal exposure to two different PFAS, perfluorooctanoic acid (PFOA) and its replacement, hexafluoropropylene oxide-dimer acid (HFPO-DA, commonly referred to as GenX).
This dataset is derived from sequencing of the same animals that were reported in GSE199233.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE262nnn/GSE262609 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE262609 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1092636 ncbi.nlm.nih.gov/bioproject/PRJNA1092636 ↗
project · from NCBI GEO
- PubMed 42483588 pubmed.ncbi.nlm.nih.gov/42483588 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE262609 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |